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Multiple microbial exposures in the home may protect against asthma or allergy in childhood

The objective of this study was to determine the influence of current GNB and GPB exposures on asthma and allergic sensitisation in school-aged children. The investigators examined the relationship between bacterial biomarkers and current asthma and allergic sensitisation in 377 school-aged children in a birth cohort study. They then evaluated the effects of school-aged endotoxin, after controlling for exposure in early life. The results indicate that exposure to GNB is inversely associated with asthma and allergic sensitisation at school age. In contrast, elevated GPB in the bed was inversely associated with current asthma, but not with allergic sensitisation. School-aged endotoxin exposure remained protective in models for allergic disease adjusted for early-life endotoxin. Both GNB and GPB exposures are associated with decreased asthma symptoms, but may act through different mechanisms to confer protection. Endotoxin exposure in later childhood is not simply a surrogate of early-life exposure; it has independent protective effects on allergic disease. Clin Exp Allergy. 2010;40(6):902-10 Published Online 13-Apr-10

Author: Sordillo JE, Hoffman EB, Celedon JC, et al

Published: 13/04/2010

Publication Type: Journal article

Publisher: Clinical and Experimental Allergy