Resource Details

Title Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.
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Author(s)Svetlíková Z; Skovierová H; Niederweis M; et al.
Abstract/Summary
Nosocomial outbreaks attributable to glutaraldehyde-resistant, rapidly growing mycobacteria are increasing. Here, evidence is provided that defects in porin expression dramatically increase the resistance of Mycobacterium smegmatis and Mycobacterium chelonae to glutaraldehyde and another aldehyde disinfectant, ortho-phthalaldehyde. Since defects in porin activity also dramatically increased the resistance of M. chelonae to drugs, there is thus some concern that the widespread use of glutaraldehyde and ortho-phthalaldehyde in clinical settings may select for drug-resistant bacteria. Antimicrob Agents Chemother. 2009;53(9):4015-8. Epub 2009 Jul 6.
PublisherAntimicrobial Agents and Chemotherapy
SourceAntimicrobial agents and chemotherapy
Publication TypeJournal article
CategoryPrevention
CoverageInternational
Date of Publishing07/06/2009
Date of posting07/30/2010